The CCDC103 Polyclonal Antibody (PAC037738) is a valuable tool for researchers studying CCDC103, a protein involved in cell cycle regulation and potential tumor suppression. This antibody, produced in rabbits, demonstrates high specificity and sensitivity when used in a variety of experimental techniques, including Western blotting. By binding to the CCDC103 protein, researchers can accurately detect and analyze its expression in various cell types, making it a versatile tool for studies in cancer biology and cell signaling pathways.
CCDC103, also known as coiled-coil domain-containing protein 103, plays a crucial role in maintaining genomic stability and preventing uncontrolled cell division, which are essential for tumor suppression. Its involvement in cell cycle regulation and potential tumor suppressive properties make it a promising target for investigating cancer development and progression. By studying the function of CCDC103, researchers can gain insights into potential therapeutic approaches for cancer treatment and prevention.
Antibody Name:
CCDC103 Antibody (PACO37738)
Antibody SKU:
PACO37738
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human Coiled-coil domain-containing protein 103 protein (1-242AA)
Western Blot. All lanes: CCDC103 antibody at 5µg/ml + Mouse heart tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 28, 12 kDa. Observed band size: 111 kDa.
Background:
Dynein-attachment factor required for cilia motility.
Synonyms:
Coiled-coil domain-containing protein 103, CCDC103
UniProt Protein Function:
CCDC103: Dynein-attachment factor required for cilia motility. Defects in CCDC103 are the cause of primary ciliary dyskinesia type 17 (CILD17). A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the CCDC103/PR46b family.Chromosomal Location of Human Ortholog: 17q21.31Cellular Component: cytoplasm; axonemeMolecular Function: protein homodimerization activityBiological Process: cell projection organization and biogenesis; heart loopingDisease: Ciliary Dyskinesia, Primary, 17
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that contains a coiled-coil domain. [provided by RefSeq, Apr 2012]
