CBY1 Antibody (PACO15727)
- SKU:
- PACO15727
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
CBY1 Antibody (PACO15727)
The CBY1 Polyclonal Antibody (PAC015727) is a valuable tool for researchers studying CBY1, a protein involved in various cellular processes, including cilia formation and cell cycle regulation. This antibody is produced in rabbits and has been validated for use in Western blot applications, where it specifically binds to the CBY1 protein.CBY1 plays a crucial role in cilia assembly and function, making it a key player in processes such as cell signaling, sensory perception, and development. Dysregulation of CBY1 has been linked to ciliopathy disorders and various cancers, highlighting its importance in human health and disease.
By using the CBY1 Polyclonal Antibody, researchers can detect and analyze CBY1 protein expression in different cell types, providing valuable insights into its function and potential therapeutic targets. This antibody is a valuable tool for studies in cell biology, developmental biology, and cancer research, helping to further our understanding of CBY1 and its role in cellular processes.
| Antibody Name: | CBY1 Antibody (PACO15727) |
| Antibody SKU: | PACO15727 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human CBY1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15727(CBY1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15727(CBY1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | chibby homolog 1 (Drosophila) |
| UniProt Protein Function: | CBY1: Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 22q12Cellular Component: cytosol; nucleoplasm; nucleus; trans-Golgi networkMolecular Function: beta-catenin binding; identical protein binding; protein bindingBiological Process: cardiac muscle cell differentiation; fat cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; protein localization |
| UniProt Protein Details: | |
| NCBI Summary: | Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3M2 |
| NCBI GenInfo Identifier: | 20454882 |
| NCBI Gene ID: | 25776 |
| NCBI Accession: | Q9Y3M2.1 |
| UniProt Secondary Accession: | Q9Y3M2,Q66GT6, Q9UIK9, B2R4S2 |
| UniProt Related Accession: | Q9Y3M2 |
| Molecular Weight: | 14,470 Da |
| NCBI Full Name: | Protein chibby homolog 1 |
| NCBI Synonym Full Names: | chibby family member 1, beta catenin antagonist |
| NCBI Official Symbol: | CBY1Â Â |
| NCBI Official Synonym Symbols: | CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15AÂ Â |
| NCBI Protein Information: | protein chibby homolog 1 |
| UniProt Protein Name: | Protein chibby homolog 1 |
| UniProt Synonym Protein Names: | ARPP-binding protein; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1 |
| Protein Family: | Protein chibby |
| UniProt Gene Name: | CBY1Â Â |
| UniProt Entry Name: | CBY1_HUMAN |
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