The CBY1 Antibody Biotin Conjugated (PACO64090) is a valuable tool for researchers studying the CBY1 protein, which plays a role in cellular processes such as ciliogenesis and microtubule organization. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in a variety of applications, including Western blot and immunofluorescence.By binding specifically to the CBY1 protein, this antibody enables researchers to detect and analyze the presence of CBY1 in different cell types, making it an ideal choice for studies in cell biology and developmental biology.
The CBY1 protein has been linked to various cellular functions, including ciliogenesis, which is essential for processes like cell signaling and sensory perception.Given the crucial role of CBY1 in cellular processes, understanding its function is important for uncovering its involvement in diseases such as ciliopathies and developmental disorders. By studying the activity of CBY1, researchers can gain insights into its potential as a therapeutic target for diseases related to ciliary dysfunction and abnormal microtubule organization.
Antibody Name:
CBY1 Antibody?Biotin conjugated (PACO64090)
Antibody SKU:
PACO64090
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein chibby homolog 1 protein (41-126AA)
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
CBY1: Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 22q12Cellular Component: cytosol; nucleoplasm; nucleus; trans-Golgi networkMolecular Function: beta-catenin binding; identical protein binding; protein bindingBiological Process: cardiac muscle cell differentiation; fat cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; protein localization
UniProt Protein Details:
NCBI Summary:
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
