HP1 alpha/CBX5 Rabbit Polyclonal Antibody (CAB12592)
- SKU:
- CAB12592
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | HP1 alpha/CBX5 Rabbit Polyclonal Antibody |
SKU: | CAB12592 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human HP1 alpha/HP1 alpha/CBX5 (NP_001120794.1). |
Sequence: | MGKK TKRT ADSS SSED EEEY VVEK VLDR RVVK GQVE YLLK WKGF SEEH NTWE PEKN LDCP ELIS EFMK KYKK MKEG ENNK PREK SESN KRKS NFSN SADD IKSK KKRE QSND IARG FERG LEPE KIIG ATDS CGDL MFLM KWKD TDEA DLVL AKEA NVKC PQIV IAFY EERL TWHA YPED AENK EKET AKS |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | HP1; HP1A; HEL25; HP1 alpha/CBX5 |
Positive Sample: | HeLa,SH-SY5Y,A-549,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, centromere. |
Calculated MW: | 22kDa |
Observed MW: | 22kDa |
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method: | Affinity purification |
Gene ID: | 23468 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |