The CBX1 Polyclonal Antibody (CAB2247) is a pivotal tool for researchers studying the CBX1 protein, which is a key component of chromatin organization and gene regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting CBX1 in human samples, making it an essential asset for Western blot applications. By binding to CBX1, this antibody enables precise detection and analysis of the protein in various cell types, facilitating investigations in epigenetics, gene expression, and chromatin dynamics.CBX1, also known as chromobox homolog 1, is a critical player in maintaining chromatin structure and regulating gene expression patterns. Dysregulation of CBX1 has been linked to various diseases, including cancer and developmental disorders, underscoring the importance of studying its function.
By delving into the role of CBX1 in chromatin modifications and transcriptional regulation, researchers can gain valuable insights into disease mechanisms and potentially uncover therapeutic targets for precision medicine approaches.Overall, the CBX1 Polyclonal Antibody is a valuable asset for researchers seeking to unravel the intricate roles of CBX1 in chromatin biology and disease pathogenesis. Its reliable performance and specificity make it a versatile tool for advancing knowledge in the fields of genetics, epigenetics, and molecular biology.
Product Name:
CBX1 Rabbit Polyclonal Antibody
SKU:
CAB2247
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HP1 beta/CBX1 (NP_006798.1).
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
10951
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of OVCAR-3 cells, using CBX1 antibody (CAB2247) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
