CBS Rabbit Monoclonal Antibody (CAB11612)
- SKU:
- CAB11612
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | CBS Rabbit Monoclonal Antibody |
SKU: | CAB11612 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-551 of human CBS (P35520). |
Sequence: | EDLT EKKP WWWH LRVQ ELGL SAPL TVLP TITC GHTI EILR EKGF DQAP VVDE AGVI LGMV TLGN MLSS LLAG KVQP SDQV GKVI YKQF KQIR LTDT LGRL SHIL EMDH FALV VHEQ IQYH STGK SSQR QMVF GVVT AIDL LNFV AAQE RDQK |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CBSL; HIP4; CBS |
Positive Sample: | HepG2,MCF7,Mouse liver,Mouse kidney,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 61kDa |
Observed MW: | 61kDa |
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 875 |
Clone Number: | ARC0643 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |