CBS Rabbit Polyclonal Antibody (CAB1427)
- SKU:
- CAB1427
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | CBS Rabbit Polyclonal Antibody |
SKU: | CAB1427 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human CBS (NP_000062.1). |
Sequence: | MPSE TPQA EVGP TGCP HRSG PHSA KGSL EKGS PEDK EAKE PLWI RPDA PSRC TWQL GRPA SESP HHHT APAK SPKI LPDI LKKI GDTP MVRI NKIG KKFG LKCE LLAK CEFF NAGG SVKD RISL RMIE DAER DGTL KPGD TIIE PTSG NTGI GLAL AAAV RGYR CIIV MPEK MSSE KVDV LRAL GAEI VRTP TNAR FDSP ESHV GVAW RLKN EIPN SHIL DQYR NASN PLAH YDTT ADEI LQQC DGKL DMLV ASVG TGGT ITGI ARKL KEKC PGCR IIGV DPEG SILA EPEE LNQT EQTT YEVE GIGY DFIP TVLD RTVV DKWF KSND EEAF TFAR MLIA QEGL LCGG SAGS TVAV AVKA AQEL QEGQ RCVV ILPD SVRN YMTK |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | CBSL; HIP4; CBS |
Positive Sample: | HepG2,293T,HeLa,MCF7,Mouse liver,Rat liver,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 61kDa |
Observed MW: | 61kDa |
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 875 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |