The CBR3 Polyclonal Antibody (CAB7545) is a crucial tool for researchers studying the CBR3 protein, an enzyme involved in the metabolism of various xenobiotics and endogenous compounds. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications.CBR3, also known as carbonyl reductase 3, plays a vital role in drug metabolism and detoxification processes in the liver. Its expression levels have been linked to drug efficacy and toxicity, making it a target of interest in pharmacology and toxicology studies.
The CBR3 Polyclonal Antibody enables researchers to detect and quantify CBR3 protein levels in different cell types, providing valuable insights into its function and potential therapeutic applications.By understanding the role of CBR3 in xenobiotic metabolism and drug response, researchers can develop new strategies for personalized medicine and drug development, ultimately improving patient outcomes and reducing adverse drug reactions. The CBR3 Polyclonal Antibody is a valuable tool for advancing research in pharmacology, toxicology, and drug discovery.
Product Name:
CBR3 Rabbit Polyclonal Antibody
SKU:
CAB7545
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 118-277 of human CBR3 (NP_001227.1).
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.
Purification Method:
Affinity purification
Gene ID:
874
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CBR3 antibody (CAB7545) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
