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CBR1 Monoclonal Antibody [4000000000000] (CPAB0442)

SKU:
CPAB0442
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2a
Clone:
4000000000000
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

CBR1 Monoclonal Antibody [4000000000000] (CPAB0442)

The CBR1 Polyclonal Antibody (CPAB0442) is a valuable tool for researchers studying CBR1, a key enzyme involved in drug metabolism and detoxification processes in the body. The antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blotting applications. By binding to the CBR1 protein, this antibody allows for the detection and analysis of CBR1 expression in a variety of cell types, making it an ideal choice for studies in pharmacology and toxicology.CBR1, also known as carbonyl reductase 1, plays a crucial role in metabolizing various endogenous and exogenous compounds, including drugs, toxins, and reactive carbonyl compounds.

Its activity is important for maintaining cellular homeostasis and protecting cells from oxidative damage. Research on CBR1 is essential for understanding drug metabolism pathways, chemical detoxification mechanisms, and the development of new therapeutic strategies for drug-related toxicity.Overall, the CBR1 Polyclonal Antibody is a valuable tool for researchers investigating the role of CBR1 in drug metabolism, toxin elimination, and cellular protection. Its high specificity and sensitivity make it a reliable choice for accurate detection and analysis of CBR1 expression in experimental settings.

Product Name:CBR1 Antibody
Product Sku:CPAB0442
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CBR1 mAb is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CBR1 protein.
Clone:4E12.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:Recombinant human CBR1 (1-277 aa ) purified from E coli.
Isotype:IgG2a
Background:CBR1 is a NADPH-dependent, monomeric, and cytosolic enzyme which is related to a family of short-chain dehydrogenases/reductases. CBR1 protein (277 a.a.) is broadly spread in human tissues such as liver, epidermis, stomach, small intestine, kidney, neuronal cells, and smooth muscle fiber. CBR1 metabolizes numerous toxic environmental quinones and pharmacological relevant substrates such as the anticancer drug, doxorubicin. The best substrates of CBR1 are quinones, including ubiquinone-1 and tocophrolquinone (vitamin E).
Synonyms:Carbonyl Reductase 1, SDR21C1, Prostaglandin-E(2) 9-reductase, NADPH-dependent carbonyl reductase 1, CBR, hCBR1, 15-hydroxyprostaglandin dehydrogenase, CRN.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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