The CBLN4 Antibody (PACO00588) is a valuable tool for research involving CBLN4, a protein involved in synaptic function and development. This polyclonal antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for studying the role of CBLN4 in neurobiology and neurodevelopmental disorders. Validated for use in various applications including Western blot, immunofluorescence, and immunohistochemistry, this antibody allows for precise detection and analysis of CBLN4 expression in different cell types and tissues.CBLN4, a member of the cerebellum-specific C1q-like protein family, is known to play a crucial role in synapse formation and maintenance, particularly in the cerebellum.
Dysregulation of CBLN4 has been implicated in various neurological conditions, making it a promising target for therapeutic interventions. By studying the function and regulation of CBLN4, researchers can gain insights into synaptic plasticity, neuronal communication, and potential treatment strategies for neurological disorders.Overall, the CBLN4 Antibody (PACO00588) offers a reliable and specific tool for investigating the biological roles of CBLN4 in the context of synaptic development and function. Its versatility and sensitivity make it a valuable asset for researchers interested in unraveling the complexities of neurobiology and identifying new therapeutic targets for neurological diseases.
Antibody Name:
CBLN4 Antibody
Antibody SKU:
PACO00588
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Monkey
Immunogen:
synthesized peptide derived from the C-terminal region of human Cerebellin 4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
CBLN4: May be involved in synaptic functions in the CNS. Can enable ER export and secretion of CBLN3.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 20q13Cellular Component: extracellular space; synapse; cell junctionBiological Process: protein secretion
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of small secreted proteins containing C1Q domains. Members of this family are involved in regulation of neurexin signalling during synapse development. The mouse homolog of the protein encoded by this gene competes with netrin to bind to the deleted in colorectal cancer receptor. [provided by RefSeq, Aug 2012]
