The CBLN3 Polyclonal Antibody (PACO22258) is specifically designed for research involving CBLN3, a protein involved in synaptic organization and functioning in the brain. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in a variety of applications, including Western blotting and immunofluorescence. By binding to the CBLN3 protein, this antibody allows for the detection and analysis of CBLN3 in different cell types, making it an ideal tool for studies in neuroscience and neurobiology research.CBLN3 is a member of the cerebellin protein family, known for their role in synaptic connectivity and synaptic plasticity in the brain.
CBLN3 specifically interacts with neurexins and plays a crucial role in the formation and maintenance of excitatory synapses. Research on CBLN3 is essential for understanding the mechanisms underlying synaptic function and dysfunction, with implications for neurological disorders such as autism, schizophrenia, and Alzheimer's disease.By utilizing the CBLN3 Polyclonal Antibody (PACO22258), researchers can unravel the intricate roles of CBLN3 in synaptic physiology and pathology, paving the way for the development of novel therapeutic approaches targeting synaptic dysfunction in neurological diseases.
Antibody Name:
CBLN3 Antibody (PACO22258)
Antibody SKU:
PACO22258
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human CBLN3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using CBLN3 antibody.
Background:
May be involved in synaptic functions in the CNS By similarity.
Synonyms:
Cerebellin-3;
UniProt Protein Function:
CBLN3: May be involved in synaptic functions in the CNS.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 14q12Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum; synapse; cell junction
UniProt Protein Details:
NCBI Summary:
Members of the precerebellin family, such as CBLN3, contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal C1q signature domain (see MIM 120550) that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix (Pang et al., 2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009]
