The CBLN1 Polyclonal Antibody (PACO00586) is a valuable tool for researchers studying CBLN1, a protein involved in synapse formation and synaptic plasticity. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CBLN1 protein, this antibody enables researchers to detect and analyze CBLN1 expression in a variety of cell types, making it well-suited for investigations in neuroscience and neurobiology.CBLN1 is an extracellular matrix protein that plays a crucial role in mediating the formation and function of excitatory synapses in the brain.
As such, understanding the function and regulation of CBLN1 is essential for unraveling the mechanisms underlying synaptic transmission and plasticity. Research on CBLN1 may yield insights into neurological disorders such as autism and schizophrenia, where abnormalities in synaptic connectivity have been implicated. By targeting CBLN1, researchers may uncover novel therapeutic strategies for addressing these conditions and advancing our understanding of brain function.
Antibody Name:
CBLN1 Antibody
Antibody SKU:
PACO00586
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human Cerebellin 1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CBLN1; Cerebellin-1; Precerebellin
UniProt Protein Function:
CBLN1: Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 16q12.1Cellular Component: postsynaptic membrane; extracellular region; cell junctionMolecular Function: protein homodimerization activityBiological Process: heterophilic cell adhesion; positive regulation of synaptogenesis; synaptic transmission; nervous system development; protein secretion; cerebellar granule cell differentiation
UniProt Protein Details:
NCBI Summary:
This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]
