The CBLL1 Polyclonal Antibody (CAB14932) is a research tool designed for studying CBLL1, a protein involved in cellular processes such as endocytosis and ubiquitination. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunofluorescence applications. By binding to CBLL1, researchers can accurately detect and analyze the protein in various cell types, making it an ideal tool for investigations in cell biology and signal transduction pathways.CBLL1, also known as E3 ubiquitin-protein ligase, plays a vital role in regulating the turnover of proteins within cells, influencing processes such as receptor signaling and protein degradation.
Its involvement in these pathways makes CBLL1 a target of interest for research into diseases related to protein dysfunction, such as cancer and neurodegenerative disorders. Understanding the function of CBLL1 is essential for developing targeted therapies that can modulate protein turnover and cellular processes in these disease contexts.
Product Name:
CBLL1 Rabbit Polyclonal Antibody
SKU:
CAB14932
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2).
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
Purification Method:
Affinity purification
Gene ID:
79872
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CBLL1 antibody (CAB14932) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
