The CBLB Polyclonal Antibody (CAB2014) is a valuable tool for researchers studying CBLB, a key player in immune regulation and T cell function. This rabbit-raised antibody is highly specific for human samples and is validated for use in Western blot applications. By targeting the CBLB protein, this antibody enables researchers to detect and analyze CBLB expression in a variety of cell types, providing insights into its role in immunology and potential implications for cancer research.CBLB, a negative regulator of T cell activation, is essential for maintaining immune tolerance and preventing autoimmunity.
Dysregulation of CBLB has been linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions. By understanding the function of CBLB, researchers can develop targeted therapies to manipulate immune responses and potentially improve treatment outcomes in these disease settings.Overall, the CBLB Polyclonal Antibody (CAB2014) is a valuable tool for researchers looking to explore the role of CBLB in immune regulation and its potential as a therapeutic target in various disease contexts.
Product Name:
CBLB Rabbit Polyclonal Antibody
SKU:
CAB2014
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 883-982 of human CBLB (NP_001308717.1).
Sequence:
PEAA LENV DAKI AKLM GE
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
Cbl-b; RNF56; Nbla00127; CBLB
Positive Sample:
Jurkat,HeLa,RPMI 8226,Mouse spleen,Rat brain
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm.
Calculated MW:
109kDa
Observed MW:
125kDa/130kDa
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections.
Purification Method:
Affinity purification
Gene ID:
868
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CBLB Rabbit pAb (CAB2014) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
