The CBL Polyclonal Antibody (CAB7881) is a valuable tool for researchers studying CBL, a crucial protein involved in cell signaling and regulation. This antibody, produced in rabbits, is specifically designed for use in detecting and analyzing CBL protein in human samples through Western blot applications. By binding to CBL, the antibody enables precise identification and characterization of this protein in various cell types.CBL is known for its role in regulating cell growth, division, and differentiation, making it a key player in processes like oncogenesis and immune response modulation. Its dysregulation has been linked to various diseases, including cancer and autoimmune disorders.
By studying the functions of CBL using this antibody, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially develop targeted therapies for treating them.Overall, the CBL Polyclonal Antibody (CAB7881) is a highly specific and reliable tool for investigating the functions of CBL in various research areas, including cancer biology, immunology, and cell signaling pathways. Its versatility and accuracy make it an essential component in any laboratory focused on understanding the intricate workings of cellular processes and disease mechanisms.
Product Name:
CBL Rabbit Polyclonal Antibody
SKU:
CAB7881
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 850-906 of human CBL (NP_005179.2).
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Purification Method:
Affinity purification
Gene ID:
867
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CBL Rabbit pAb (CAB7881) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
