CBFB Rabbit Polyclonal Antibody (CAB5305)
- SKU:
- CAB5305
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | CBFB Rabbit Polyclonal Antibody |
SKU: | CAB5305 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-182 of human CBFB (NP_001746.1). |
Sequence: | MPRV VPDQ RSKF ENEE FFRK LSRE CEIK YTGF RDRP HEER QARF QNAC RDGR SEIA FVAT GTNL SLQF FPAS WQGE QRQT PSRE YVDL EREA GKVY LKAP MILN GVCV IWKG WIDL QRLD GMGC LEFD EERA QQED ALAQ QAFE EARR RTRE FEDR DRSH REEM EVRV SQLL AVTG KKTT RP |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CLCD2; PEBP2B; CBFB |
Positive Sample: | HeLa,NIH/3T3,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 22kDa |
Observed MW: | 22kDa |
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 865 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |