The CBFA2T3 Polyclonal Antibody (CAB14712) is a valuable tool for research involving the CBFA2T3 protein, a transcriptional corepressor involved in hematopoietic development and cell differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.CBFA2T3 plays a crucial role in the regulation of gene expression and cell fate determination, making it a key player in developmental processes and cancer progression. By targeting the CBFA2T3 protein, researchers can investigate its function in various cell types and gain insights into its involvement in hematopoiesis and tumorigenesis.
The CBFA2T3 Polyclonal Antibody is a reliable tool for studying the molecular mechanisms underlying hematopoietic development and cell differentiation, providing valuable information for cancer research and therapeutic development. Its specificity and sensitivity make it an ideal choice for researchers looking to explore the role of CBFA2T3 in health and disease.
Product Name:
CBFA2T3 Rabbit Polyclonal Antibody
SKU:
CAB14712
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 593-653 of human CBFA2T3 (NP_005178.4).
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
Purification Method:
Affinity purification
Gene ID:
863
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CBFA2T3 Rabbit pAb (CAB14712) at 1:900 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 90s.
