The Cavin2 Polyclonal Antibody is a powerful tool for researchers studying Cavin2, a protein involved in caveolae formation and cell signaling. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the Cavin2 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential resource for studies in cell biology and signal transduction.Cavin2, also known as PTRF (polymerase I and transcript release factor), plays a crucial role in the organization and function of caveolae, specialized membrane structures involved in various cellular processes.
Its involvement in cell signaling pathways and membrane dynamics makes it a key player in understanding cellular functions related to lipid metabolism, vesicular trafficking, and signal transduction. Research on Cavin2 is vital for investigating diseases such as cardiovascular disorders, insulin resistance, and cancer, where dysregulation of caveolae and lipid metabolism are implicated.By utilizing the Cavin2 Polyclonal Antibody in their research, scientists can gain valuable insights into the role of Cavin2 in cellular processes and disease pathways, ultimately paving the way for the development of novel therapeutic strategies targeting caveolae-related disorders.
Product Name:
CAVIN2 Polyclonal Antibody
SKU:
CAB23889
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 325-425 of human CAVIN2（NP_004648.1）.
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.
Purification Method:
Affinity purification
Gene ID:
8436
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CAVIN2 Rabbit pAb (CAB23889) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
