The Caveolin-3 Rabbit Monoclonal Antibody (CAB4891) is a specialized research tool designed for studying Caveolin-3, a crucial protein involved in various cellular processes, especially in the context of muscle and cardiac function. This antibody is produced using rabbit monoclonal technology, ensuring high specificity and sensitivity in detecting Caveolin-3 in human samples.Caveolin-3 is a key structural component of caveolae, small invaginations in the plasma membrane that play essential roles in signaling, lipid metabolism, and protein trafficking. Dysregulation of Caveolin-3 has been implicated in various diseases, including muscular dystrophies and cardiovascular disorders.
By targeting Caveolin-3 with this antibody, researchers can investigate its expression levels, localization, and interactions in different cell types and tissues.This antibody has been validated for use in Western blot applications, enabling researchers to quantify Caveolin-3 expression levels and study its molecular characteristics. Given the importance of Caveolin-3 in muscle and heart biology, this antibody is a valuable tool for investigations in cardiology, muscle physiology, and related fields. By elucidating the functions of Caveolin-3, researchers can uncover new insights into disease mechanisms and potentially identify novel therapeutic targets.
Product Name:
Caveolin-3 Rabbit Monoclonal Antibody
SKU:
CAB4891
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-151 of human Caveolin-3 (P56539).
This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
Purification Method:
Affinity purification
Gene ID:
859
Clone Number:
ARC2473
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Caveolin-3 Rabbit mAb (CAB4891) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
