The Caveolin-3 Polyclonal Antibody (CAB8089) is a powerful tool for research focused on caveolin-3, a key protein involved in various cellular functions, particularly in muscle cells. This antibody, produced in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blot applications.Caveolin-3 is a structural protein found in caveolae, small invaginations in the plasma membrane that play a crucial role in signal transduction and lipid regulation. Dysregulation of caveolin-3 has been implicated in various muscle disorders, making it a prime target for research in muscle biology and neuromuscular diseases.
By specifically recognizing caveolin-3, this antibody enables researchers to study the expression and localization of this important protein in different cell types, providing valuable insights into its function and potential implications in disease pathology. With its reliability and specificity, the Caveolin-3 Polyclonal Antibody is an essential tool for advancing our understanding of caveolin-3 biology and its potential therapeutic applications in muscle-related disorders.
Product Name:
Caveolin-3 Rabbit Polyclonal Antibody
SKU:
CAB8089
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-151 of human Caveolin-3 (NP_001225.1).
This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
Purification Method:
Affinity purification
Gene ID:
859
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Caveolin-3 Rabbit pAb (CAB8089) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 60s.
