The Cav3 Polyclonal Antibody (CAB12769) is a valuable tool for researchers studying Cav3, a calcium channel protein known for its role in cell signaling and muscle contraction. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Cav3 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential reagent for studies in physiology and neuroscience.Cav3, also referred to as T-type calcium channel, is essential for regulating calcium influx in excitable cells, such as neurons and cardiac muscle cells.
Dysregulation of Cav3 has been implicated in various diseases, including epilepsy, arrhythmias, and cancer. By understanding the function and expression of Cav3, researchers can uncover new insights into disease mechanisms and potentially develop targeted therapies for these conditions.Overall, the Cav3 Polyclonal Antibody (CAB12769) serves as a crucial tool for investigating the role of Cav3 in cellular physiology and disease pathology, offering valuable opportunities for advancing scientific knowledge and therapeutic development.
Product Name:
Caveolin-3 Rabbit Polyclonal Antibody
SKU:
CAB12769
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Caveolin-3 (NP_001225.1).
This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
Purification Method:
Affinity purification
Gene ID:
859
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Caveolin-3 Rabbit pAb (CAB12769) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
