The CATSPER4 Polyclonal Antibody (PACO36806) is a valuable tool for researchers investigating CATSPER4, a protein crucial for the function of sperm cells. This antibody, produced in rabbits, exhibits high reactivity to human samples and is validated for use in Western blot applications. By binding specifically to the CATSPER4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in reproductive biology and infertility research.
CATSPER4 is a key player in sperm motility and fertility, making it a promising target for studies on male infertility and potential therapeutic interventions. Understanding the role of CATSPER4 in sperm function is essential for developing strategies to address fertility issues and advance reproductive medicine. This antibody provides researchers with a reliable tool for further exploring the intricate mechanisms underlying sperm cell function and male reproductive health.
Immunofluorescent analysis of Hela cells using PACO36806 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO36806 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human liver cancer using PACO36806 at dilution of 1:100.
Background:
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-α = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Synonyms:
Cation channel sperm-associated protein 4 (CatSper4), CATSPER4
