| UniProt Protein Function: | CATSPER2: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Defects in CATSPER2 are a cause of deafness-infertility syndrome (DIS). DIS is characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 15q15.3Cellular Component: plasma membraneMolecular Function: protein binding; voltage-gated calcium channel activityBiological Process: response to progesterone stimulus; sperm motility; sperm-egg recognitionDisease: Deafness, Sensorineural, And Male Infertility; Spermatogenic Failure 7 |
| UniProt Protein Details: | |
| NCBI Summary: | Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014] |
| UniProt Code: | Q96P56 |
| NCBI GenInfo Identifier: | 156631018 |
| NCBI Gene ID: | 117155 |
| NCBI Accession: | Q96P56.2 |
| UniProt Secondary Accession: | Q96P56,Q8NHT9, Q96P54, Q96P55 |
| UniProt Related Accession: | Q96P56 |
| Molecular Weight: | 23,437 Da |
| NCBI Full Name: | Cation channel sperm-associated protein 2 |
| NCBI Synonym Full Names: | cation channel sperm associated 2 |
| NCBI Official Symbol: | CATSPER2Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | cation channel sperm-associated protein 2 |
| UniProt Protein Name: | Cation channel sperm-associated protein 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Cation channel sperm-associated protein |
| UniProt Gene Name: | CATSPER2Â Â |
| UniProt Entry Name: | CTSR2_HUMAN |
