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CATSPER2 Antibody (PACO39034)

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SKU:
PACO39034
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • CATSPER2 Antibody PACO39034
  • CATSPER2 Antibody PACO39034
  • CATSPER2 Antibody PACO39034
€359

Description

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CATSPER2 Antibody (PACO39034)

The Catsper2 Polyclonal Antibody (PACO39034) is a powerful tool for researchers studying the Catsper2 protein, which is essential for sperm function and male fertility. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the Catsper2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in reproductive biology and infertility research.Catsper2, a critical component of the Catsper ion channel complex, is involved in regulating calcium influx in sperm cells, which is essential for sperm motility and fertilization.

Dysfunction of Catsper2 has been implicated in male infertility and may be a target for developing novel fertility treatments. Research on Catsper2 is crucial for advancing our understanding of male reproductive health and developing strategies to address infertility issues in men.Overall, the Catsper2 Polyclonal Antibody (PACO39034) offers researchers a reliable tool for studying the role of Catsper2 in male fertility and reproductive biology, with the potential to contribute to advancements in the field of assisted reproductive technologies and infertility treatments.

Antibody Name:CATSPER2 Antibody (PACO39034)
Antibody SKU:PACO39034
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Cation channel sperm-associated protein 2 protein (5-112AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot. All lanes: CATSPER2 antibody at 4µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: HepG2 whole cell lysate. Lane 3: 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 63, 62, 49, 24 kDa. Observed band size: 63 kDa.
Product ImageImmunofluorescent analysis of LO2 cells using PACO39034 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human spleen tissue using PACO39034 at dilution of 1:100.
Background:Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-α = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Synonyms:Cation channel sperm-associated protein 2 (CatSper2), CATSPER2
UniProt Protein Function:CATSPER2: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Defects in CATSPER2 are a cause of deafness-infertility syndrome (DIS). DIS is characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 15q15.3Cellular Component: plasma membraneMolecular Function: protein binding; voltage-gated calcium channel activityBiological Process: response to progesterone stimulus; sperm motility; sperm-egg recognitionDisease: Deafness, Sensorineural, And Male Infertility; Spermatogenic Failure 7
UniProt Protein Details:
NCBI Summary:Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
UniProt Code:Q96P56
NCBI GenInfo Identifier:156631018
NCBI Gene ID:117155
NCBI Accession:Q96P56.2
UniProt Secondary Accession:Q96P56,Q8NHT9, Q96P54, Q96P55
UniProt Related Accession:Q96P56
Molecular Weight:23,437 Da
NCBI Full Name:Cation channel sperm-associated protein 2
NCBI Synonym Full Names:cation channel sperm associated 2
NCBI Official Symbol:CATSPER2  
NCBI Official Synonym Symbols:
NCBI Protein Information:cation channel sperm-associated protein 2
UniProt Protein Name:Cation channel sperm-associated protein 2
UniProt Synonym Protein Names:
Protein Family:Cation channel sperm-associated protein
UniProt Gene Name:CATSPER2  
UniProt Entry Name:CTSR2_HUMAN
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