The Cathepsin S Polyclonal Antibody (CAB1874) is specifically designed for research involving Cathepsin S, a lysosomal cysteine proteinase involved in antigen processing and presentation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.Cathepsin S is known for its role in the immune system, specifically in the degradation of antigens for presentation to T cells. This process is crucial for the activation of immune responses and the regulation of inflammatory reactions.
Research on Cathepsin S is particularly relevant in the fields of immunology, cancer, and autoimmune diseases, where dysregulation of antigen processing can have significant impacts on disease progression.Overall, the Cathepsin S Polyclonal Antibody is a valuable tool for studying the function and regulation of Cathepsin S in various cell types and biological contexts. Its high specificity and sensitivity make it an essential component for researchers looking to delve deeper into the complex mechanisms of immune activation and antigen presentation.
Product Name:
CTSS Rabbit Polyclonal Antibody
SKU:
CAB1874
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 115-331 of human CTSS (NP_004070.3).
The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves the invariant chain of MHC class II molecules in endolysosomal compartments and enables the formation of antigen-MHC class II complexes and the proper display of extracellular antigenic peptides by MHC-II. The mature protein also functions as an elastase over a broad pH range. When secreted from cells, this protein can remodel components of the extracellular matrix such as elastin, collagen, and fibronectin. This gene is implicated in the pathology of many inflammatory and autoimmune diseases and, given its elastase activity, plays a significant role in some pulmonary diseases. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1520
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CTSS Rabbit pAb (CAB1874) at 1:800 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 10s.
