The Cathepsin L1 Polyclonal Antibody (CAB12200) is a valuable tool for researchers studying Cathepsin L1, a lysosomal cysteine proteinase involved in various physiological processes such as protein degradation, cell signaling, and immune response regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.Cathepsin L1 is known to play a key role in cancer progression, inflammation, and tissue remodeling, making it a promising target for therapeutic interventions in cancer and inflammatory diseases. By detecting and measuring the levels of Cathepsin L1 in different cell types, researchers can gain valuable insights into its function and potential as a biomarker or therapeutic target.
This antibody offers a reliable tool for investigating the role of Cathepsin L1 in various biological processes and diseases, providing a better understanding of its mechanisms of action and potential implications for clinical applications. Its high specificity and sensitivity make it suitable for a wide range of research applications in the fields of immunology, cancer biology, and drug development.
Product Name:
Cathepsin L/V/K/H Rabbit Polyclonal Antibody
SKU:
CAB12200
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 114-333 of human Cathepsin L/V/K/H (NP_001903.1).
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
Purification Method:
Affinity purification
Gene ID:
1514
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from LO2 cells, using Cathepsin L/V/K/H Rabbit pAb (CAB12200) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
