Cathepsin L/V/K/H Rabbit Polyclonal Antibody (CAB12200)
- SKU:
- CAB12200
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Cathepsin L/V/K/H Rabbit Polyclonal Antibody |
SKU: | CAB12200 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 114-333 of human Cathepsin L/V/K/H (NP_001903.1). |
Sequence: | APRS VDWR EKGY VTPV KNQG QCGS CWAF SATG ALEG QMFR KTGR LISL SEQN LVDC SGPQ GNEG CNGG LMDY AFQY VQDN GGLD SEES YPYE ATEE SCKY NPKY SVAN DTGF VDIP KQEK ALMK AVAT VGPI SVAI DAGH ESFL FYKE GIYF EPDC SSED MDHG VLVV GYGF ESTE SDNN KYWL VKNS WGEE WGMG GYVK MAKD RRNH CGIA SAAS YPTV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | MEP; CATL; CTSL1; Cathepsin L/V/K/H |
Positive Sample: | Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome. |
Calculated MW: | 38kDa |
Observed MW: | 38kDa |
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
Purification Method: | Affinity purification |
Gene ID: | 1514 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |