The Cathepsin L1 Polyclonal Antibody (CAB12066) is a vital tool for researchers studying Cathepsin L1, an important enzyme involved in various cellular processes, including protein degradation and tissue remodeling. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards Cathepsin L1 in human samples, making it an excellent choice for Western blot applications.Cathepsin L1 is a lysosomal proteinase known for its role in protein catabolism and its involvement in disease pathogenesis, particularly in cancer progression and metastasis. By targeting Cathepsin L1 with this polyclonal antibody, researchers can delve deeper into its function and signaling pathways in different cell types, paving the way for advancements in cancer research, drug development, and therapeutic interventions targeting Cathepsin L1.
The utilization of the Cathepsin L1 Polyclonal Antibody is instrumental in unraveling the intricate mechanisms underlying Cathepsin L1's contribution to physiological and pathological processes, offering valuable insights that may lead to novel treatment strategies for various human diseases.
Product Name:
Cathepsin L/V/K/H Rabbit Polyclonal Antibody
SKU:
CAB12066
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 114-333 of human Cathepsin L/V/K/H (NP_001903.1).
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
Purification Method:
Affinity purification
Gene ID:
1514
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cathepsin L/V/K/H Rabbit pAb (CAB12066) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
