The Cathepsin D Rabbit Monoclonal Antibody (CAB19680) is a high-quality research tool specifically designed for studying Cathepsin D, a lysosomal protease involved in protein degradation and cellular homeostasis. This antibody, generated in rabbits, exhibits strong reactivity towards human samples and has been validated for use in various applications such as Western blotting.Cathepsin D is a key enzyme involved in lysosomal function and is known to play a critical role in various physiological processes, including cell growth, differentiation, and apoptosis. Dysregulation of Cathepsin D has been implicated in several diseases, making it a promising target for research in fields such as cancer biology, neurodegenerative disorders, and metabolic diseases.
By utilizing the Cathepsin D Rabbit Monoclonal Antibody (CAB19680), researchers can effectively detect and analyze Cathepsin D protein levels in different cell types, providing valuable insights into its function and potential therapeutic applications. This antibody is a valuable tool for scientists conducting studies in the fields of biochemistry, cell biology, and molecular biology.
Product Name:
Cathepsin D Rabbit Monoclonal Antibody
SKU:
CAB19680
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 313-412 of human Cathepsin D (P07339).
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
Purification Method:
Affinity purification
Gene ID:
1509
Clone Number:
ARC0160
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cathepsin D Rabbit mAb (CAB19680) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
