The Cathepsin D Polyclonal Antibody (CAB1594) is a valuable tool for researchers studying Cathepsin D, an important lysosomal protease involved in various cellular processes, including protein degradation and cell death. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Cathepsin D plays a critical role in the regulation of autophagy, apoptosis, and cell proliferation, making it a key player in cancer progression and neurodegenerative diseases. By targeting Cathepsin D with this antibody, researchers can effectively detect and analyze its expression in different cell types, allowing for in-depth studies in the fields of oncology and neurobiology.
Understanding the function and regulation of Cathepsin D is essential for developing targeted therapies for diseases where dysregulation of this protease is implicated. With the Cathepsin D Polyclonal Antibody (CAB1594), researchers can delve deeper into the mechanisms underlying these diseases, ultimately paving the way for novel therapeutic interventions.
Product Name:
Cathepsin D Rabbit Polyclonal Antibody
SKU:
CAB1594
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 65-412 of human Cathepsin D (NP_001900.1).
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
Purification Method:
Affinity purification
Gene ID:
1509
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Cathepsin D antibody (CAB1594) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
