The Cathepsin B Polyclonal Antibody (CAB0967) is a valuable tool for researchers studying the role of Cathepsin B, a lysosomal cysteine protease involved in various physiological processes including protein degradation, antigen presentation, and apoptosis. This antibody, generated in rabbits, shows high specificity and sensitivity towards human samples, making it suitable for use in Western blot experiments.Cathepsin B is a key player in cancer progression, metastasis, and invasion, making it a potential therapeutic target for cancer treatment.
By detecting and analyzing the expression of Cathepsin B in different cell types, researchers can uncover its role in tumor development and identify potential drug targets.Furthermore, Cathepsin B has been implicated in various other diseases such as neurodegenerative disorders, cardiovascular diseases, and inflammatory conditions. Studying the activity of Cathepsin B using this antibody can provide insights into its role in these pathologies, leading to the development of novel treatments and diagnostic tools.
Product Name:
Cathepsin B Rabbit Polyclonal Antibody
SKU:
CAB0967
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-339 of human Cathepsin B (NP_001899.1).
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified.
Purification Method:
Affinity purification
Gene ID:
1508
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cathepsin B Rabbit pAb (CAB0967) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
