Cathepsin B Rabbit Polyclonal Antibody (CAB0967)
- SKU:
- CAB0967
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Cathepsin B Rabbit Polyclonal Antibody |
SKU: | CAB0967 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-339 of human Cathepsin B (NP_001899.1). |
Sequence: | RSRP SFHP LSDE LVNY VNKR NTTW QAGH NFYN VDMS YLKR LCGT FLGG PKPP QRVM FTED LKLP ASFD AREQ WPQC PTIK EIRD QGSC GSCW AFGA VEAI SDRI CIHT NAHV SVEV SAED LLTC CGSM CGDG CNGG YPAE AWNF WTRK GLVS GGLY ESHV GCRP YSIP PCEH HVNG SRPP CTGE GDTP KCSK ICEP GYSP TYKQ DKHY GYNS YSVS NSEK DIMA EIYK NGPV EGAF SVYS DFLL YKSG VYQH VTGE MMGG HAIR ILGW GVEN GTPY WLVA NSWN TDWG DNGF FKIL RGQD HCGI ESEV VAGI PRTD QYWE KI |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | KWE; APPS; CPSB; RECEUP; Cathepsin B |
Positive Sample: | HepG2,A375,HT-1080,Rat kidney,Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome, Melanosome, Secreted, extracellular space. |
Calculated MW: | 38kDa |
Observed MW: | 24kDa/27kDa/44kDa |
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified.
Purification Method: | Affinity purification |
Gene ID: | 1508 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |