[KO Validated] β-Catenin Rabbit Polyclonal Antibody (CAB11512)
- SKU:
- CAB11512
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
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Description
Product Name: | [KO Validated] β-Catenin Rabbit Polyclonal Antibody |
SKU: | CAB11512 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 667-781 of human β-Catenin (NP_001895.1). |
Sequence: | PQDY KKRL SVEL TSSL FRTE PMAW NETA DLGL DIGA QGEP LGYR QDDP SYRS FHSG GYGQ DALG MDPM MEHE MGGH HPGA DYPV DGLP DLGH AQDL MDGL PPGD SNQL AWFD TDL |
Tested Applications: | WB IHC-P IP ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:20 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | EVR7; CTNNB; MRD19; NEDSDV; armadillo; β-Catenin |
Positive Sample: | Mouse brain,Mouse lung,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cytoplasm, Nucleus, adherens junction, centrosome, cytoskeleton, microtubule organizing center, spindle pole. |
Calculated MW: | 85kDa |
Observed MW: | 92kDa |
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1499 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |