[KO Validated] α-Catenin Rabbit Polyclonal Antibody (CAB5635)
- SKU:
- CAB5635
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | [KO Validated] α-Catenin Rabbit Polyclonal Antibody |
SKU: | CAB5635 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 637-906 of human α-Catenin (NP_001894.2). |
Sequence: | ELDD SDFE TEDF DVRS RTSV QTED DQLI AGQS ARAI MAQL PQEQ KAKI AEQV ASFQ EEKS KLDA EVSK WDDS GNDI IVLA KQMC MIMM EMTD FTRG KGPL KNTS DVIS AAKK IAEA GSRM DKLG RTIA DHCP DSAC KQDL LAYL QRIA LYCH QLNI CSKV KAEV QNLG GELV VSGV DSAM SLIQ AAKN LMNA VVQT VKAS YVAS TKYQ KSQG MASL NLPA VSWK MKAP EKKP LVKR EKQD ETQT KIKR ASQK KHVN PVQA LSEF KAMD SI |
Tested Applications: | WB IHC-P IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | MDBS2; MDPT2; CAP102; in |
Positive Sample: | BT-474,OVCAR3,293T,MCF7,Mouse lung,Mouse heart,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, adherens junction, cytoskeleton. |
Calculated MW: | 100kDa |
Observed MW: | 115kDa |
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy.
Purification Method: | Affinity purification |
Gene ID: | 1495 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |