The Catenin Alpha 1 Polyclonal Antibody (CAB5635) is a valuable tool for researchers studying the Catenin Alpha 1 protein, which plays a crucial role in cell adhesion and signaling pathways. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the Catenin Alpha 1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in cell biology and cancer research.Catenin Alpha 1 is a key component of the cadherin-catenin complex, which mediates cell-cell adhesion and is essential for maintaining tissue integrity and organization.
Dysregulation of this complex has been implicated in various diseases, including cancer and developmental disorders. By studying the function of Catenin Alpha 1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the Catenin Alpha 1 Polyclonal Antibody is a valuable tool for investigating the role of Catenin Alpha 1 in cellular processes and disease development. Its high specificity and sensitivity make it an essential reagent for researchers looking to advance our understanding of cell adhesion and signaling pathways.
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy.
Purification Method:
Affinity purification
Gene ID:
1495
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] α-Catenin Rabbit pAb (CAB5635) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
