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[KO Validated] α-Catenin Rabbit Polyclonal Antibody (CAB5635)

SKU:
CAB5635
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • KO Validated Antibodies 1 Anti-Alpha-Catenin Antibody CAB5635KO Validated
  • KO Validated Antibodies 1 Anti-Alpha-Catenin Antibody CAB5635KO Validated
  • KO Validated Antibodies 1 Anti-Alpha-Catenin Antibody CAB5635KO Validated
  • KO Validated Antibodies 1 Anti-Alpha-Catenin Antibody CAB5635KO Validated
  • KO Validated Antibodies 1 Anti-Alpha-Catenin Antibody CAB5635KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] α-Catenin Rabbit Polyclonal Antibody
SKU:CAB5635
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 637-906 of human α-Catenin (NP_001894.2).
Sequence:ELDD SDFE TEDF DVRS RTSV QTED DQLI AGQS ARAI MAQL PQEQ KAKI AEQV ASFQ EEKS KLDA EVSK WDDS GNDI IVLA KQMC MIMM EMTD FTRG KGPL KNTS DVIS AAKK IAEA GSRM DKLG RTIA DHCP DSAC KQDL LAYL QRIA LYCH QLNI CSKV KAEV QNLG GELV VSGV DSAM SLIQ AAKN LMNA VVQT VKAS YVAS TKYQ KSQG MASL NLPA VSWK MKAP EKKP LVKR EKQD ETQT KIKR ASQK KHVN PVQA LSEF KAMD SI
Tested Applications:WB IHC-P IP ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:MDBS2; MDPT2; CAP102; in
Positive Sample:BT-474,OVCAR3,293T,MCF7,Mouse lung,Mouse heart,Mouse brain
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, adherens junction, cytoskeleton.
Calculated MW:100kDa
Observed MW:115kDa

This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy.

Purification Method:Affinity purification
Gene ID:1495
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using [KO Validated] α-Catenin Rabbit pAb (CAB5635) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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