The Catalase Polyclonal Antibody (CAB11777) is a valuable tool for studying the enzyme catalase, which plays a crucial role in protecting cells from oxidative damage by catalyzing the breakdown of hydrogen peroxide into water and oxygen. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an excellent choice for research in biochemistry and cell biology.Catalase is found in all aerobic cells and is particularly abundant in cells that are exposed to high levels of oxygen, such as liver and kidney cells. Dysregulation of catalase activity has been linked to various diseases, including cancer, diabetes, and neurodegenerative disorders, making it an attractive target for therapeutic interventions.
By using the Catalase Polyclonal Antibody, researchers can detect and quantify catalase levels in different cell types and tissues, providing valuable insights into its role in oxidative stress-related diseases. This antibody is validated for use in Western blot applications, offering reliable and reproducible results for a wide range of research projects.
Product Name:
Catalase Rabbit Polyclonal Antibody
SKU:
CAB11777
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human Catalasealase (NP_001743.1).
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.
Purification Method:
Affinity purification
Gene ID:
847
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Catalase Rabbit pAb (CAB11777) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
