The CASZ1 Polyclonal Antibody (PAC061646) is a valuable tool for researchers studying CASZ1, a transcription factor involved in heart development and cancer. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards CASZ1 in human samples, making it suitable for Western blot and immunofluorescence applications.CASZ1, also known as Castor zinc finger 1, plays a crucial role in cardiac morphogenesis and has been implicated in various types of cancer. Its function as a transcriptional regulator makes it an intriguing target for investigating molecular pathways in heart disease and oncogenesis.
By enabling the detection and visualization of CASZ1 in different cell types, this antibody facilitates detailed exploration of its role in development and disease progression.Researchers in the fields of cardiac biology, oncology, and developmental biology will find the CASZ1 Polyclonal Antibody invaluable for uncovering the intricate mechanisms by which CASZ1 influences cellular processes. Its reliability and versatility make it a valuable resource for advancing our understanding of CASZ1 biology and its implications in human health and disease.
Western Blot. Positive WB detected in: Jurkat whole cell lysate. All lanes: CASZ1 antibody at 4.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 191, 125 kDa. Observed band size: 191 kDa.
IHC image of PACO61646 diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
Synonyms:
Zinc finger protein castor homolog 1, Castor-related protein, Putative survival-related protein, Zinc finger protein 693, CASZ1, CST, SRG, ZNF693
UniProt Protein Function:
CASZ1: Probable transcription factor. 2 isoforms of the human protein are produced by alternative splicing.Protein type: C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factorChromosomal Location of Human Ortholog: 1p36.22Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasmMolecular Function: DNA binding; metal ion bindingBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
