The CASZ1 Polyclonal Antibody (PAC020967) is a valuable tool for researchers studying CASZ1, a transcription factor known for its role in heart development and neuroblastoma suppression. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in immunofluorescence and immunohistochemistry applications.CASZ1, a zinc finger transcription factor, plays a crucial role in regulating gene expression during cardiac development, making it a promising target for studying heart diseases and congenital abnormalities. Additionally, CASZ1 has been identified as a tumor suppressor in neuroblastoma, a pediatric cancer of the nervous system, highlighting its potential importance in cancer research.
By using the CASZ1 Polyclonal Antibody, researchers can detect and analyze the expression of CASZ1 in various tissues and cell types, providing valuable insights into its function and potential therapeutic implications. This antibody enables researchers to further explore the mechanisms through which CASZ1 influences developmental processes and tumor progression, ultimately advancing our understanding of cardiovascular development and neuroblastoma pathogenesis.
Antibody Name:
CASZ1 Antibody (PACO20967)
Antibody SKU:
PACO20967
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human CASZ1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20967(CASZ1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Synonyms:
castor zinc finger 1
UniProt Protein Function:
CASZ1: Probable transcription factor. 2 isoforms of the human protein are produced by alternative splicing.Protein type: C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factorChromosomal Location of Human Ortholog: 1p36.22Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasmMolecular Function: DNA binding; metal ion bindingBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
