The Castor2 Polyclonal Antibody (PAC063407) is a reliable tool for researchers studying the protein Castor2, which plays a role in immune regulation and inhibits immune responses. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications.Castor2 is a key molecule involved in immune homeostasis, helping to regulate inflammation and prevent excessive immune responses. Research into Castor2 has shown its potential relevance in studying diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
Understanding the function of Castor2 is essential for developing targeted therapies that modulate immune response in these disease contexts.The Castor2 Polyclonal Antibody enables researchers to detect and analyze Castor2 protein levels in various cell types, making it a valuable tool for studies in immunology and cancer research. By targeting Castor2, researchers can gain valuable insights into immune regulation and potentially identify new therapeutic targets for immune-related diseases.
Antibody Name:
CASTOR2 Antibody (PACO63407)
Antibody SKU:
PACO63407
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA)
Western Blot. Positive WB detected in: HL60 whole cell lysate, SH-SY5Y whole cell lysate, Jurkat whole cell lysate, Hela whole cell lysate. All lanes: CASTOR2 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 37 kDa. Observed band size: 37 kDa.
Background:
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Synonyms:
Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2), CASTOR2, GATSL1 GATSL2
UniProt Protein Function:
GATSL2: Belongs to the GATS family.Chromosomal Location of Human Ortholog: 7q11.23
