The CASR Polyclonal Antibody (CAB1426) is a valuable tool for researchers studying the Calcium-sensing receptor (CASR), a key regulator of calcium homeostasis and signaling pathways. This antibody, generated in rabbits, specifically targets the CASR protein in human samples and is validated for use in Western blot applications. By detecting and analyzing CASR expression in various cell types, this antibody is ideal for investigations in endocrinology, bone metabolism, and kidney function research.CASR is involved in maintaining calcium levels in the body and is implicated in a wide range of physiological processes, including bone mineralization, hormone secretion, and renal function.
Dysregulation of CASR activity is associated with disorders such as hyperparathyroidism, hypocalcemia, and certain cancers. By studying CASR expression and function, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets for intervention.
Product Name:
CASR Rabbit Polyclonal Antibody
SKU:
CAB1426
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-536 of human CASR (NP_000379.3).
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia.
Purification Method:
Affinity purification
Gene ID:
846
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CASR Rabbit pAb (CAB1426) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
