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CASQ2 Monoclonal Antibody [PAT4E10AT] (CPAB0443)

SKU:
CPAB0443
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT4E10AT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

CASQ2 Monoclonal Antibody [PAT4E10AT] (CPAB0443)

The CASQ2 Polyclonal Antibody (CPAB0443) is a valuable tool for researchers studying CASQ2, a protein found in the cardiac muscle and essential for calcium ion storage. This antibody, produced in rabbits, specifically targets CASQ2 in human samples and is validated for use in Western blot applications.CASQ2 is a key player in maintaining proper calcium levels in cardiac muscle cells, crucial for proper muscle contraction and relaxation. Dysregulation of CASQ2 has been implicated in various cardiac disorders, including arrhythmias and heart failure.

Research into CASQ2 signaling and function is vital for understanding these cardiac conditions and developing targeted therapies.With its high reactivity and specificity for CASQ2, this antibody is an ideal choice for researchers looking to study the role of this protein in cardiac physiology and pathology. Its applications in Western blotting allow for accurate and reliable detection of CASQ2 in various cell types, making it a valuable asset in cardiovascular research.

Product Name:CASQ2 Antibody
Product Sku:CPAB0443
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CASQ2 mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CASQ2 amino acids 2-399 purified from Ecoli.
Clone:PAT4E10AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:CASQ2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:CASQ2 belongs to the calsequestrin family and is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. CASQ2 is a calcium binding protein that stores calcium for muscle function. The discharge of calcium bound to CASQ2 through a calcium release channel activates muscle contraction. CASQ2 binds 40 to 50 moles of calcium. CASQ2 mutations result in stress-induced polymorphic ventricular tachycardia, also called catecholaminergic polymorphic ventricular tachycardia 2 which is known fir its bidirectional ventricular tachycardia that causes cardiac arrest.
Synonyms:PDIB2, CASQ2, Calsequestrin-2, Calsequestrin cardiac muscle isoform, FLJ26321, FLJ93514.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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