Caspase-9 Rabbit Polyclonal Antibody (CAB11451)
- SKU:
- CAB11451
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | Caspase-9 Rabbit Polyclonal Antibody |
SKU: | CAB11451 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Caspase-9 (NP_001220.2). |
Sequence: | VYGT DGCP VSVE KIVN IFNG TSCP SLGG KPKL FFIQ ACGG EQKD HGFE VAST SPED ESPG SNPE PDAT PFQE GLRT FDQL DAIS SLPT PSDI FVSY STFP G |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; Caspase-9 |
Positive Sample: | L929,293T,Jurkat,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | apoptosome, cytoplasm, cytosol, mitochondrion, nucleus |
Calculated MW: | 46kDa |
Observed MW: | 47kDa/35kDa/37kDa |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 842 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |