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[KO Validated] Caspase-9 Rabbit Polyclonal Antibody (CAB0281)

SKU:
CAB0281
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • KO Validated Antibodies 1 Anti-Caspase-9 Antibody CAB0281KO Validated
  • KO Validated Antibodies 1 Anti-Caspase-9 Antibody CAB0281KO Validated
  • KO Validated Antibodies 1 Anti-Caspase-9 Antibody CAB0281KO Validated
  • KO Validated Antibodies 1 Anti-Caspase-9 Antibody CAB0281KO Validated
  • KO Validated Antibodies 1 Anti-Caspase-9 Antibody CAB0281KO Validated
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] Caspase-9 Rabbit Polyclonal Antibody
SKU:CAB0281
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 139-416 of Caspase-9 (NP_001220.2).
Sequence:VGAL ESLR GNAD LAYI LSME PCGH CLII NNVN FCRE SGLR TRTG SNID CEKL RRRF SSLH FMVE VKGD LTAK KMVL ALLE LAQQ DHGA LDCC VVVI LSHG CQAS HLQF PGAV YGTD GCPV SVEK IVNI FNGT SCPS LGGK PKLF FIQA CGGE QKDH GFEV ASTS PEDE SPGS NPEP DATP FQEG LRTF DQLD AISS LPTP SDIF VSYS TFPG FVSW RDPK SGSW YVET LDDI FEQW AHSE DLQS LLLR VANA VSVK GIYK QMPG CFNF LRKK LFFK TS
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:100 - 1:500 IF/ICC,1:50 - 1:200
Synonyms:MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; Caspase-9
Positive Sample:HepG2,293T
Conjugate:Unconjugated
Cellular Localization:apoptosome, cytoplasm, cytosol, mitochondrion, nucleus
Calculated MW:46kDa
Observed MW:35kDa/37kDa/47kDa

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:842
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageImmunohistochemistry analysis of Caspase-9 in paraffin-embedded mouse kidney tissue using Caspase-9 Rabbit pAb (CAB0281) at a dilution of 1:300 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

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