The Caspase-7 Polyclonal Antibody (CAB1524) is a valuable tool for researchers studying apoptosis and cell death pathways. Caspase-7, a critical enzyme in the caspase family, plays a key role in the execution phase of apoptosis by cleaving specific substrates. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting Caspase-7 in human samples, making it ideal for use in Western blot applications.Caspase-7 is involved in various physiological processes, including tissue development, immune response, and regulation of cell death. Dysregulation of caspase-7 activity has been implicated in various diseases, such as cancer, neurodegenerative disorders, and autoimmune conditions.
Studying the expression and function of caspase-7 can provide insights into the mechanisms underlying these diseases and may lead to the development of novel therapeutic strategies targeting apoptosis pathways.By using the Caspase-7 Polyclonal Antibody, researchers can detect and analyze the levels of Caspase-7 in different cell types and tissues, contributing to a better understanding of its role in health and disease. This antibody is a valuable tool for investigating the molecular mechanisms of apoptosis and exploring potential therapeutic interventions targeting caspase-7 signaling pathways.
Product Name:
Caspase-7 Rabbit Polyclonal Antibody
SKU:
CAB1524
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human Caspase-7 (NP_001218.1).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
840
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat liver, using Caspase-7 Rabbit pAb (CAB1524) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
