The Caspase-6 Rabbit Monoclonal Antibody (CAB19559) is an essential tool for researchers studying caspase-6, a key enzyme in the caspase family involved in apoptosis regulation. This antibody, generated in rabbits, shows high specificity and sensitivity for human samples, making it reliable for Western blotting applications. By binding to caspase-6 protein, researchers can accurately detect and analyze its expression in various cell types, making it ideal for studies in cell biology, apoptosis, and cancer research.Caspase-6 is known for its role in apoptosis, particularly in neuronal cell death and neurodegenerative diseases.
Understanding the regulation and activity of caspase-6 is crucial for unraveling its implications in diseases like Alzheimer's and Huntington's, paving the way for potential therapeutic interventions. The Caspase-6 Rabbit Monoclonal Antibody provides a precise tool for investigating the role of caspase-6 in cell death pathways and disease progression, offering valuable insights for drug development and treatment strategies.
Product Name:
Caspase-6 Rabbit Monoclonal Antibody
SKU:
CAB19559
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Caspase-6 (P55212).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
Purification Method:
Affinity purification
Gene ID:
839
Clone Number:
ARC0038
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Caspase-6 antibody (CAB19559) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
