The Caspase-6 Rabbit Monoclonal Antibody (CAB19552) is a powerful tool for researchers studying apoptosis and cell death processes. Caspase-6 is a key player in the cascade of events leading to programmed cell death, making this antibody essential for investigating these pathways in various cell types.This antibody, developed using rabbits, offers high specificity and sensitivity for detecting Caspase-6 protein in human samples. Validated for Western blot applications, it allows for precise detection and analysis of Caspase-6 levels in experimental settings. Caspase-6 is particularly relevant in cancer research, where dysregulation of apoptosis pathways can contribute to tumorigenesis and resistance to therapy.
By targeting Caspase-6, researchers can gain insights into how these processes are altered in cancer cells, potentially leading to the development of novel therapeutic strategies.Overall, the Caspase-6 Rabbit Monoclonal Antibody (CAB19552) is a valuable tool for scientists studying cell death mechanisms in health and disease, providing crucial insights into the role of Caspase-6 in various pathological conditions.
Product Name:
Caspase-6 Rabbit Monoclonal Antibody
SKU:
CAB19552
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 45-162 of human Caspase-6 (P55212).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
Purification Method:
Affinity purification
Gene ID:
839
Clone Number:
ARC0031
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Caspase-6 antibody (CAB19552) at 1:1000 dilution.Jurkat cells were treated by Staurosporine(1uM) at room temperature for 3 hours .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
