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Caspase-3 p17 Polyclonal Antibody (CAB21677)

SKU:
CAB21677
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
€139 - €529
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Caspase-3 p17 Polyclonal Antibody
SKU:CAB21677
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-175 of human Caspase-3 (NP_004337.2).
Sequence:SGIS LDNS YKMD YPEM GLCI IINN KNFH KSTG MTSR SGTD VDAA NLRE TFRN LKYE VRNK NDLT REEI VELM RDVS KEDH SKRS SFVC VLLS HGEE GIIF GTNG PVDL KKIT NFFR GDRC RSLT GKPK LFII QACR GTEL DCGI ETD
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:CPP32; SCA-1; CPP32B; 17
Positive Sample:293T,Jurkat,Mouse lung
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:32kDa
Observed MW:32kDa/17kDa

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

Purification Method:Affinity purification
Gene ID:836
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse lung, using [KO Validated] Caspase-3 p17 Rabbit pAb (CAB21677) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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