Caspase-3 p12 Rabbit Monoclonal Antibody (CAB19664)
- SKU:
- CAB19664
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | Caspase-3 p12 Rabbit Monoclonal Antibody |
SKU: | CAB19664 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 176-277 of human Caspase-3 p12 (P42574). |
Sequence: | SGVD DDMA CHKI PVEA DFLY AYST APGY YSWR NSKD GSWF IQSL CAML KQYA DKLE FMHI LTRV NRKV ATEF ESFS FDAT FHAK KQIP CIVS MLTK ELYF YH |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CPP32; SCA-1; CPP32B; Caspase-3 p12 |
Positive Sample: | Mouse liver,NIH/3T3,Rat spleen,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 32kDa |
Observed MW: | 12kDa/30kDa |
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Purification Method: | Affinity purification |
Gene ID: | 836 |
Clone Number: | ARC0143 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |