The Caspase-2 Rabbit Monoclonal Antibody (CAB4888) is a valuable tool for researchers studying the caspase-2 protein, a key player in the apoptotic pathway. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the caspase-2 protein, this antibody enables precise detection and analysis in various cell types, providing valuable insights into apoptosis and its role in disease processes.Caspase-2 is a critical regulator of apoptosis, with implications in cancer, neurodegenerative diseases, and other pathological conditions.
By targeting caspase-2, researchers can better understand the mechanisms of cell death and explore potential therapeutic interventions. The Caspase-2 Rabbit Monoclonal Antibody is a versatile tool for investigating the function and regulation of caspase-2 in different biological contexts, advancing our knowledge of apoptosis and its implications for human health.
Product Name:
Caspase-2 Rabbit Monoclonal Antibody
SKU:
CAB4888
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 334-452 of human Caspase-2 (P29594).
Sequence:
GKNH TQSP GCEE SDAG KEEL MKMR LPTR SDMI CGYA CLKG NAAM RNTK RGSW YIEA LTQV FSER ACDM HVAD MLVK VNAL IKER EGYA PGTE FHRC KEMS EYCS TLCQ QLYL FPGY PPT
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
835
Clone Number:
ARC0317
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Caspase-2 pAb (CAB4888) at 1:1000 dilution.Jurkat cells were treated by Staurosporine (1uM) for 3 hours.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
