The Caspase-2 Polyclonal Antibody (CAB5724) is a valuable tool for researchers studying the role of caspase-2, a member of the caspase family of proteases that plays a crucial role in apoptosis, or programmed cell death. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.Caspase-2 is known for its involvement in various cellular processes, including DNA repair, cell cycle regulation, and cell death. Dysregulation of caspase-2 has been linked to a variety of diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
By targeting caspase-2 with this antibody, researchers can gain insights into its function and potential therapeutic applications.Whether exploring the mechanisms of apoptosis, investigating disease pathways, or developing potential treatments, the Caspase-2 Polyclonal Antibody offers a reliable tool for studying this key protease. Its reactivity with human samples and versatility in Western blot applications make it a valuable asset for research in cell biology, cancer biology, and beyond.
Product Name:
Caspase-2 Rabbit Polyclonal Antibody
SKU:
CAB5724
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 153-452 of human Caspase-2 (NP_116764.2).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
835
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CASP2 Polyclonal Antibody (CAB5724) at 1:1000 dilution.Jurkat cells were treated by Staurosporine(1uM) at room temperature for 3 hours .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
