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Caspase-14 Rabbit Polyclonal Antibody (CAB6541)

SKU:
CAB6541
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
  • Developmental Biology Anti-Caspase-14 Antibody CAB6541
  • Developmental Biology Anti-Caspase-14 Antibody CAB6541
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Caspase-14 Rabbit Polyclonal Antibody
SKU:CAB6541
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human Caspase-14 (NP_036246.1).
Sequence:MSNP RSLE EEKY DMSG ARLA LILC VTKA REGS EEDL DALE HMFR QLRF ESTM KRDP TAEQ FQEE LEKF QQAI DSRE DPVS CAFV VLMA HGRE GFLK GEDG EMVK LENL FEAL NNKN CQAL RAKP KVYI IQAC RGEQ RDPG ETVG GDEI VMVI KDSP QTIP TYTD ALHV YSTV EGYI AYRH DQKG SCFI QTLV DVFT KRKG HILE LLTE VTRR MAEA ELVQ EGKA RKTN PEIQ STLR KRLY LQ
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:ARCI12; Caspase-14
Positive Sample:HepG2,293T
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:28kDa
Observed MW:28-29kDa

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Purification Method:Affinity purification
Gene ID:23581
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using Caspase-14 antibody (CAB6541) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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